Placed in Group A of the Europa League, Arsenal and PSV Eindhoven occupy the first and second positions respectively.
Both sides have been impressive in their respective domestic leagues and are nearly unstoppable every time they take to the pitch.
With pressure mounting on Leicester manager Brendan Rodgers, he will be desperate for the club to climb out of the bottom spot.
They are both winless in their last three league games, hence Thursday provides a great opportunity for them to end that barren run.
Sitting third in the Premier League table, Tottenham Hotspur have 23 points from ten games. They have already won seven of those matches.
Sitting fifth in the Premier League table, Manchester United have 16 points from nine matches. They have seven points less than third-placed Spurs.
Watford are placed tenth in the standings with 20 points from 14 games. They are just two points shy of the sixth spot in the table.
Sitting second in the table with 25 points from 14 games, Sheffield United trail EFL Championship leaders Burnley by just goal difference.
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Sitting at the top of the standings with 25 points from 14 games, Burnley have been the team to keep an eye out for this time around.